What is Selank?
Selank is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It was created by combining the sequence of tuftsin (an immunomodulatory peptide) with a stabilizing Pro-Gly-Pro sequence, similar to the modification used in Semax.
Unlike Semax (ACTH-derived, cognitive-focused), Selank is primarily studied for its anxiolytic (anti-anxiety) properties while also demonstrating nootropic effects. It has been approved in Russia for anxiety and related conditions.
Development and Origin
Tuftsin Foundation
Selank is based on tuftsin, a natural tetrapeptide:
Tuftsin:
Selank Modification:
Timeline
Russian Approved Indications:
Mechanism of Action
GABAergic System
Primary anxiolytic mechanism:
GABA Enhancement:
Key Distinction:
Unlike benzodiazepines, Selank:
Serotonergic Modulation
5-HT System Effects:
Neurotrophic Effects
BDNF and NGF:
Immune-Neuroendocrine
From Tuftsin Heritage:
Peptide Profile
| Property | Details |
|---|---|
| Full Name | Selank (TP-7) |
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| Base Peptide | Tuftsin (Thr-Lys-Pro-Arg) |
| Amino Acids | 7 (heptapeptide) |
| Molecular Weight | 751.9 g/mol |
| Purity | 99%+ (HPLC verified) |
| Form | Lyophilized powder or nasal solution |
Research Applications
Anxiety Research
Anxiolytic Studies:
Comparison Studies:
Cognitive Research
Nootropic Effects:
Stress-Cognition:
Neuroprotection
Protective Studies:
Immune Function
Immunomodulation:
Selank vs Semax: Detailed Comparison
Primary Effects
| Aspect | Selank | Semax |
|---|---|---|
| Primary Action | Anxiolytic | Cognitive enhancement |
| Origin | Tuftsin-based | ACTH fragment |
| Mood Effect | Calming | Activating |
| Energy | Neutral/calming | Stimulating |
| Best For | Anxiety, stress | Focus, learning |
Mechanism Comparison
| Pathway | Selank | Semax |
|---|---|---|
| GABA | Strong modulation | Minimal |
| Dopamine | Moderate | Strong |
| Serotonin | Yes | Yes |
| BDNF | Yes | Yes (strong) |
| NGF | Yes | Yes |
Enjoying this article?
Subscribe to get notified when we publish new experiment reports and research findings.
No spam, unsubscribe anytime.
Choosing Between Them
Choose Selank When:
Choose Semax When:
Combination:
Some researchers study both together for balanced effects.
See our Semax guide.
Dosage Protocols in Research
Administration Routes
Nasal (Most Common):
Subcutaneous (Research):
Reconstitution (Lyophilized)
| Vial Size | Bacteriostatic Water | Concentration |
|---|---|---|
| 5mg | 5ml | 1mg/ml |
| 10mg | 10ml | 1mg/ml |
Use our peptide calculator for precise measurements.
Selank
5mg • 99%+ Purity
$29.99
In Stock
Research Dosing Ranges
Nasal Administration:
Subcutaneous:
Specific dosing should follow institutional guidelines.
Storage Guidelines
Lyophilized Form
Reconstituted/Solution
See our storage guide.
Safety Profile
Clinical Experience (Russia)
Documented Profile:
Reported Effects:
Advantages Over Traditional Anxiolytics
| Aspect | Benzodiazepines | Selank |
|---|---|---|
| Sedation | Strong | None |
| Dependency | High risk | Not reported |
| Tolerance | Develops | Not reported |
| Cognitive | Impairment | Enhancement |
| Withdrawal | Significant | Not reported |
Considerations
Frequently Asked Questions
How is Selank different from benzodiazepines?
Selank modulates GABA-A receptors but doesn't directly bind benzodiazepine sites like traditional benzodiazepines. This produces anxiolytic effects without sedation, dependency, tolerance, or cognitive impairment—major advantages over benzodiazepines.
Can Selank be combined with Semax?
Research has examined both peptides together. Semax provides cognitive activation while Selank provides calming effects, potentially balancing each other. Specific combination protocols depend on research goals.
Does Selank cause drowsiness?
No. Unlike benzodiazepines and many anxiolytics, Selank does not cause sedation or drowsiness. It's anxiolytic without being sedating, which is a key advantage for daytime use in research settings.
How does Selank affect cognition?
While primarily anxiolytic, Selank has nootropic properties including memory enhancement and improved cognitive function under stress. The reduction of anxiety may itself improve cognitive performance by reducing stress-related impairment.
Is Selank approved anywhere?
Selank is approved in Russia for anxiety-related conditions and has been in clinical use since 2009. It is not FDA approved in the United States but is available for research purposes.
What is the connection between Selank and immunity?
Selank is derived from tuftsin, a natural immunomodulatory peptide. It retains some immune effects including cytokine modulation and may influence the immune-neuroendocrine axis. This distinguishes it from most other anxiolytic compounds.
Related Resources
Conclusion
Selank represents a unique approach to anxiety research—providing anxiolytic effects through GABA modulation without the drawbacks of traditional anxiolytics. Its tuftsin-derived structure adds immunomodulatory properties not found in other anti-anxiety compounds.
For researchers studying anxiety, stress, or the intersection of immune and nervous system function, Selank provides a well-characterized tool with extensive Russian clinical data.
Explore our Selank products and nasal spray options.
Related Nootropic Peptides
View All
This article is for informational purposes only. Selank is sold for research purposes and is not FDA approved. All research should be conducted in accordance with applicable regulations.
