Melanotan I
10mg · 99%+ Purity
Description
Melanotan I stimulates melanogenesis, leading to increased melanin production and UV protection in cellular models. Research explores its potential role in DNA repair mechanisms following UV exposure.
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Research & Science
Evidence-based information about this compound
Chemical Properties
CAS Number
75921-69-6
Molecular Formula
C78H111N21O19
Molecular Weight
1646.85 g/mol
Amino Acid Sequence
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Also known as:
Afamelanotide, CUV1647, NDP-α-MSH
Melanotan 1 (Afamelanotide) is a linear synthetic analog of α-melanocyte stimulating hormone (α-MSH), consisting of 13 amino acids. Unlike the cyclic Melanotan 2, MT-1 is a linear peptide with more selective melanocortin receptor activity.
MT-1 was developed to provide tanning effects through MC1R activation while minimizing off-target effects on other melanocortin receptors. It has progressed further in clinical development than MT-2, with regulatory approvals in some jurisdictions for specific conditions.
The peptide is particularly relevant to research on photoprotection and conditions involving defective melanin production.
Melanotan 1 acts primarily through MC1R:
- MC1R Selectivity: More selective for melanocortin 1 receptor than MT-2.
- Melanogenesis: Stimulates melanin production in melanocytes.
- Eumelanin: Promotes production of darker, photoprotective eumelanin.
- DNA Repair: May enhance UV-induced DNA damage repair mechanisms.
- Reduced Side Effects: Lower affinity for MC3R/MC4R means fewer off-target effects.
MT-1's photoprotective properties have been clinically studied:
- Erythropoietic Protoporphyria: Approved for EPP in some regions.
- UV Tolerance: Increases time to sunburn in fair-skinned individuals.
- DNA Protection: May enhance DNA repair after UV exposure.
- Melanin Density: Increases protective melanin in skin.
Clinical trials have established its photoprotective efficacy.
Sources:
MT-1 has advanced clinical development:
- FDA Approval: Approved for erythropoietic protoporphyria.
- Safety Profile: Well-characterized safety from clinical trials.
- Vitiligo: Studied for repigmentation in vitiligo patients.
- Polymorphous Light Eruption: Investigated for sun-sensitive skin conditions.
MT-1 is one of the few melanocortin peptides with regulatory approval.
Sources:
This information is provided for educational purposes only and is based on published scientific research. This product is intended for research use only.
