Kisspeptin-10
5mg · 99%+ Purity
Description
Buy Kisspeptin-10 peptide 5mg at 99%+ purity. Researched for reproductive hormone regulation and testosterone support.
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Research & Science
Evidence-based information about this compound
Chemical Properties
CAS Number
374675-21-5
Molecular Formula
C63H83N17O14
Molecular Weight
1302.43 g/mol
Amino Acid Sequence
Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Also known as:
Kisspeptin 10, KP-10, Metastin 45-54
Kisspeptin-10 is a 10-amino acid fragment of the larger kisspeptin protein, encoded by the KISS1 gene. It represents the minimally active sequence required for full receptor activation. Kisspeptin plays a central role in the regulation of reproductive hormone release through the hypothalamic-pituitary-gonadal (HPG) axis.
The peptide acts on the kisspeptin receptor (KISS1R, formerly GPR54) in the hypothalamus, making it a master regulator of GnRH release and consequently LH and FSH secretion. This places kisspeptin at the apex of the reproductive hormone cascade.
Research interest in kisspeptin spans from basic reproductive physiology to potential therapeutic applications in fertility and puberty disorders.
Kisspeptin-10 controls reproductive hormones through a specific pathway:
- KISS1R Activation: Binds to kisspeptin receptors on GnRH neurons in the hypothalamus.
- GnRH Release: Stimulates pulsatile release of gonadotropin-releasing hormone.
- LH/FSH Secretion: GnRH triggers pituitary release of luteinizing hormone and follicle-stimulating hormone.
- Gonadal Stimulation: LH and FSH stimulate testosterone/estrogen production and gamete development.
- Feedback Integration: Kisspeptin neurons integrate steroid hormone feedback.
Kisspeptin's role in reproduction is fundamental:
- Puberty Initiation: Required for the onset of puberty; mutations cause hypogonadism.
- LH Pulses: Generates pulsatile LH release essential for fertility.
- Ovulation: Kisspeptin surge triggers LH surge and ovulation in females.
- Testosterone: Stimulates testosterone production in males through LH.
Kisspeptin is the gatekeeper of reproductive function.
Kisspeptin has significant fertility research applications:
- IVF Trigger: Being studied as an alternative to hCG for oocyte maturation.
- Hypogonadism: Potential therapy for hypothalamic causes of infertility.
- PCOS Research: Dysregulated kisspeptin may contribute to PCOS pathology.
- Safety Profile: May offer advantages over current fertility treatments.
Clinical trials are ongoing for various reproductive applications.
Sources:
This information is provided for educational purposes only and is based on published scientific research. This product is intended for research use only.
