CJC-1295: Research Overview
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) with significant modifications to extend its biological activity. It comes in two primary forms: CJC-1295 with DAC (Drug Affinity Complex) and CJC-1295 without DAC (also called Modified GRF 1-29).
Peptide Variants
CJC-1295 with DAC
| Property | Details |
|---|---|
| Type | GHRH analog + DAC |
| Amino Acids | 30 |
| DAC | Lysine linked to maleimidopropionic acid |
| Half-life | Extended (days) |
| Molecular Weight | ~3647 g/mol |
CJC-1295 without DAC (MOD GRF 1-29)
| Property | Details |
|---|---|
| Type | Modified GHRH (1-29) |
| Amino Acids | 29 |
| DAC | None |
| Half-life | Short (minutes) |
| Molecular Weight | ~3367 g/mol |
Understanding GHRH
Natural GHRH
Growth hormone-releasing hormone:
The Challenge
Natural GHRH limitations:
CJC-1295 Modifications
Amino Acid Substitutions
Key modifications for stability:
The DAC Technology
Drug Affinity Complex (DAC):
Research Applications
GH Axis Research
Comparative Studies
| Comparison | Research Focus |
|---|---|
| With DAC vs. without DAC | Duration of action |
| CJC-1295 vs. natural GHRH | Stability/potency |
| CJC-1295 + GHRP | Synergistic effects |
Combination Research
Often studied with:
Reconstitution Protocol
Standard Volumes
| Variant | Vial Size | BAC Water | Concentration |
|---|---|---|---|
| With DAC | 2mg | 2ml | 1,000mcg/ml |
| Without DAC | 2mg | 2ml | 1,000mcg/ml |
| Without DAC | 5mg | 2.5ml | 2,000mcg/ml |
Procedure
Storage Guidelines
Lyophilized
Reconstituted
Choosing Between Variants
CJC-1295 with DAC
Best for:
CJC-1295 without DAC (MOD GRF)
Best for:
Physical Properties
Lyophilized:
Reconstituted:
Quality Indicators
Acceptable
Problems
Conclusion
CJC-1295 provides researchers with stable GHRH analogs for studying the growth hormone axis. The choice between DAC and non-DAC versions depends on whether sustained or pulsatile activity is desired for specific research applications.
*CJC-1295 is sold for research purposes only and is not approved for human use.*
Frequently Asked Questions
What is the difference between CJC-1295 with DAC and without DAC?
CJC-1295 with DAC has a Drug Affinity Complex that allows albumin binding, creating extended activity lasting days. Without DAC (MOD GRF 1-29), activity is much shorter (minutes), allowing for pulsatile GH release studies.
Why is CJC-1295 often combined with Ipamorelin?
CJC-1295 (GHRH analog) and Ipamorelin (GHRP) work through different receptors that synergize for GH release. The combination is studied to examine additive or synergistic effects on the GH axis.
What modifications make CJC-1295 more stable than natural GHRH?
CJC-1295 has amino acid substitutions including D-alanine at position 2 (DPP-IV resistance) and leucine replacing methionine at position 27 (oxidation resistance). These changes dramatically improve stability.
Need Help with Dosing?
Use our calculator to determine exact amounts for your research.
Peptide Calculator