GHK-Cu: Copper Peptide Overview
GHK-Cu (Glycyl-L-Histidyl-L-Lysine:Copper) is a naturally occurring tripeptide with high affinity for copper(II) ions. First isolated from human plasma in 1973, it has become a subject of extensive research in wound healing, skin biology, and cellular signaling.
Peptide Profile
| Property | Details |
|---|---|
| Full Name | Glycyl-L-Histidyl-L-Lysine:Copper(II) |
| Sequence | Gly-His-Lys |
| Amino Acids | 3 (tripeptide) |
| Metal Ion | Copper(II) / Cu²⁺ |
| Molecular Weight | ~340 g/mol (without Cu), ~403 g/mol (with Cu) |
| Purity | 99%+ (HPLC verified) |
| Form | Lyophilized powder (blue-tinted) |
Unique Properties
Copper Binding
GHK naturally binds copper with high affinity. The complex forms through:
This creates a stable, bioavailable copper complex.
Natural Occurrence
GHK-Cu is found naturally in:
Plasma concentrations decline with age, which has driven research interest in its biological roles.
Research Applications
Skin and Dermal Research
Copper Biology
Cell Biology
Comparative Studies
Mechanism Research Areas
GHK-Cu research has explored several mechanisms:
Gene Expression
Studies have examined GHK-Cu's effects on:
Copper Delivery
As a copper carrier, GHK-Cu may:
Physical Characteristics
Appearance
Lyophilized:
Reconstituted:
Solubility
Highly soluble in:
Reconstitution Protocol
Standard Volumes
| Vial Size | BAC Water | Concentration |
|---|---|---|
| 50mg | 2ml | 25mg/ml |
| 100mg | 4ml | 25mg/ml |
| 200mg | 5ml | 40mg/ml |
*GHK-Cu often comes in larger quantities due to typical research concentrations.*
Procedure
Storage Guidelines
Lyophilized
| Storage | Temperature | Duration |
|---|---|---|
| Long-term | -20°C | 2+ years |
| Short-term | 2-8°C | 12+ months |
Reconstituted
Research Considerations
Copper Content
When designing experiments, consider:
Controls
Useful controls for GHK-Cu research:
Concentration Ranges
Typical research concentrations:
Quality Verification
Expected Characteristics
Signs of Issues
Related Research Peptides
| Peptide | Relationship |
|---|---|
| GHK (free) | Same peptide, no copper |
| AHK-Cu | Alanine variant |
| DAHK | Related copper-binding sequence |
Conclusion
GHK-Cu's unique copper-binding properties make it a valuable research tool in dermal biology, wound healing research, and copper metabolism studies. Its natural occurrence and well-characterized structure support diverse research applications.
*GHK-Cu is sold for research purposes only and is not intended for human use.*
Frequently Asked Questions
Why is GHK-Cu blue in color?
The blue color comes from the copper(II) ion bound to the peptide. This is characteristic of copper complexes and indicates proper copper content. Loss of blue color may indicate copper loss or degradation.
What's the difference between GHK and GHK-Cu?
GHK is the free tripeptide (Gly-His-Lys), while GHK-Cu is the same peptide complexed with a copper(II) ion. The copper-bound form has distinct properties and is how the peptide naturally occurs in the body.
Is GHK-Cu stable in solution?
Yes, GHK-Cu is relatively stable due to the copper complex. Reconstituted solutions can be stored refrigerated for 4-8 weeks. The copper actually adds stability compared to many other peptides.
Need Help with Dosing?
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